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Vitamin D Deficiency: A Silent Epidemic!

Boston, MA (PRWEB) June 06, 2011
The Endocrine Society Releases Clinical Practice Guidelines:
30-60 ng/ml or 75-150 nmol/L

Ontario (PRWEB) June 06, 2011
Canadian Public Health Releases Clinical Practice Guidelines:
40-60 ng/ml or 100-150 nmol/L

Disease Incidence Prevention by Serum 25(OH)D Level
Chart prepared by: C.F. Garland, Dr.P.H., FACE

What's your vitamin D level?
Find out on-line

Free "Symposium in Print" - 2009 - Annals of Epidemiology

Experts Respond to IOM's Controversial RDAs for Vitamin D

"The IOM recommendations for vitamin D fail in a major way on logic, on science, and on effective public health guidance. Moreover, by failing to use a physiological referent, the IOM approach constitutes precisely the wrong model for development of nutritional policy." Heaney, R., Holick, M., J Bone Miner Res. 2011 Mar;26(3):455-7
“We determined vitamin D receptor (VDR) binding throughout the human genome using chromatin immunoprecipitation.........we identified 2776 genomic positions occupied by the VDR and 229 genes with significant changes in expression in response to vitamin D. VDR binding sites were significantly enriched near autoimmune and cancer associated genes...
.....included IRF8, associated with MS, and PTPN2 associated with Crohn's disease and Type 1 Diabetes.” Genome Research 2010 Aug; 20: 1352-1360

"The upper limit (UL) should be increased to at least 5,000 IU/day, based on expected benefits compared to anticipated minor risks. Some knowledgeable vitamin D scientists and physicians have recommended a higher UL of 10,000 IU/day based on a critical examination of published studies of toxicity balanced against benefits [131]." Annals of Epidemiology 2009 July:19(7):468-483

"Vitamin D inhibits the uptake of cholesterol by cells called macrophages," explained lead researcher Carlos Bernal-Mizrachi, MD. "When people are deficient in vitamin D, the macrophage cells eat more cholesterol, and they can't get rid of it. The macrophages get clogged with cholesterol and become what scientists call foam cells, which are one of the earliest markers of atherosclerosis." Circulation 2009 August:120:687-698

"These results from a nationally representative US sample show that systolic BP and pulse pressure are inversely associated with serum 25OHD... The inverse association between serum 25OHD and systolic BP has clinical significance, because the latter variable is a better predictor of coronary heart disease risk than diastolic BP, particularly in older people" Am J Hypertension 2007 July:20:713-9

"Vitamin D sufficiency was strongly associated with decreased risk for PTL/PTB and infection during pregnancy and comorbities of pregnancy, with the greatest effect with 4000 IU vitamin D/day regimen. Therefore, to attain a minimal 25(OH)D level of 40ng/mL, we recommend 4000 IU/day for all pregnant women." Platform Session: Randomized Clinical Trial: Neonatal Fetal Nutrition & Metabolism 2010 May: Vancouver, British Columbia

"It's likely that more than one-third of older adults now have vitamin D levels associated with higher risks of death and few have levels associated with optimum survival," said lead author Adit Ginde, MD, MPH. J Am Geriatic Soc 2009 September:57:1595-1603

"Regardless of vitamin D's effects on innate immunity, activated vitamin D is a pluripotent pleiotropic seco-steroid with as many mechanisms of action as the 1,000 human genes it regulates [93]. Evidence continues to accumulate of vitamin D's involvement in a breathtaking array of human disease and death [40,41]." Virology J 2008 February:5:29

"In asthma, reduced vitamin D levels are associated with impaired lung function, increased airway hyperresponsiveness and reduced glucocorticoid response, suggesting that supplementation of vitamin D levels in patients with asthma may improve multiple parameters of asthma severity and treatment response." Am J Respir Crit Care Med 2010 April: 181:699-704

"The results of our study suggest that high circulating levels of vitamin D are associated with a lower risk of multiple sclerosis." JAMA 2006 December:296:2832-2838

"1,25-dihydroxyvitamin D (active form of vitamin D: calcitriol) acts as an immune system modulator, preventing excessive expression of inflammatory cytokines and increasing the 'oxidative burst' potential of macrophages. Perhaps most importantly, it dramatically stimulates the expression of potent anti-microbial peptides, which exist in neutrophils, monocytes, natural killer cells, and in epithelial cells lining the respiratory tract where they play a major role in protecting the lung from infection." Epidemiology & Infection 2006 December:134(6):1129-40

"2,000 IU of vitamin D per day abolished the seasonality of influenza (see Figure 2) and dramatically reduced its self-reported incidence [25]." Virology Journal 2008 February:5:29

"Androgen levels and 25(OH)D levels are associated in men and reveal a concordant seasonal variation." Clinical Endocrinology [Epub ahead of print] due 2010

"We speculate that symptomatic myalgia in statin-treated patients with concurrent vitamin D deficiency may reflect a reversible interaction between vitamin D deficiency and statins on skeletal muscle." Translational Research: J of Lab and Clin Med 2009 Jan:153(1):11-6

D3 vs D2
"D3 is approximately 87% more potent in raising and maintaining serum 25(OH)D concentrations and produces 2- to 3-fold greater storage of vitamin D than does equimolar D2....Given its greater potency and lower cost, D3 should be the preferred treatment option when correcting vitamin D deficiency."J Clin Endocrinol Metab.2011; 96: E447-E452

"The data presented in this paper indicate that the 50,000 IU dosage form of vitamin D2 should be considered to be equivalent to no more than 15,000 IU of vitamin D3 and perhaps closer to only 5,000 IU."J Clin Endo Med 2004 November:89(11):5387-91

"The case that VITAMIN D2 SHOULD NO LONGER BE CONSIDERED EQUIVALENT TO VITAMIN D3 is based on differences in their efficacy at raising serum 25-hydroxyvitamin D, diminished binding of vitamin D2 metabolites to vitamin D binding protein in plasma, and a nonphysiologic metabolism and shorter shelf life of vitamin D2. VITAMIN D2, OR ERGOCALCIFEROL, SHOULD NOT BE REGARDED AS A NUTRIENT SUITABLE FOR SUPPLEMENTATION OR FORTIFICATION." Am J Clin Nutr 2006 October:84(4):694-7

View Michael Holick, Ph.D., M.D., Vitamin D - An Overview (58min)
View Robert P. Heaney, M.D., Vitamin D Deficiency (44min)
View Cedric F. Garland, Dr.P.H., FACE, Vitamin D Deficiency and Cancer (40min)
View Frank C. Garland, Ph.D., Vitamin D and Diabetes (48min)
View David Sane, M.D., Vitamin D and Cardiovascular Disease (46min)

SEE Vitamin D Metabolized (click "next")
University of Washington Department of Medicine

"Humans make thousands of units of vitamin D within minutes of whole body exposure to sunlight. From what we know of nature, it is unlikely such a system evolved by chance."   John Cannell, M.D., Vitamin D Council.

"It seems clear that restoring physiological serum levels of 25(OH)D will help many more patients than it will hurt. In fact, living in America today while worrying about vitamin D toxicity is like dying of thirst in the desert while worrying about drowning."
John Cannell, M.D., Vitamin D Council.

N P R: Medical Schools and Drug Firm Dollars

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